Biochemical Factors in Behavior Disorders, ADHD and Mental Illness

Because of access to a large database of biochemical information from more than 10,000 patients with mental health problems, examination of this data shows that most of these persons have striking abnormalities in specific nutrients required for neurotransmitter production.  The most common chemical imbalances we encountered include the following:

Over-Methylation

Many persons who suffer from anxiety and depression are over-methylated which results in excessive levels of dopamine, norepinephrine and serotonin. Typical symptoms include chemical and food sensitivities, underachievement, upper body pain, and an adverse reaction to serotonin-enhancing substances such as Prozac, Paxil, Zoloft, St. John’s Wort, and SAMe.  They have a genetic tendency to be very depressed in folates and other B vitamins.  Biochemical treatment focuses on supplementation of these nutrients.  These persons are also overloaded in copper and methionine and supplements of these nutrients must be strictly avoided.

Under-Methylation

Many patients with obsessive-compulsive tendencies, oppositional-defiant disorder, or seasonal depression are under-methylated which is associated with low serotonin levels. They generally exhibit seasonal allergies, perfectionism, competitiveness, and other distinctive symptoms and traits. They have a genetic tendency to be very depressed in calcium, magnesium, methionine, and Vitamin B-6 with excessive levels of folic acid. These under-methylated persons may benefit nicely from Paxil, Zoloft, and other serotonin-enhancing medications, although nasty side effects are common. A more natural approach is to directly correct the underlying problem using methionine, calcium, magnesium, amongst others.

Metal-Metabolism

A common problem in ADHD, behavior disorders, and hormonal depression is a genetic inability to control copper, zinc, manganese, and other trace metals in the body due to improper functioning of the metallothionine protein.  These patients are often deficient in trace metals, amino acids, and Vitamin B-6 and overloaded in others.  They must avoid supplements and “enriched” foods containing copper. In addition, we recommend they drink bottled water and limit use of swimming pools and jacuzzis treated with copper sulfate anti-algae agents.  Foods to be limited due to high copper content include shellfish, chocolate, and carob.  Elevated copper levels are associated with hormonal imbalances and a classic symptom is intolerance to estrogen. Biochemical treatment focuses on stimulation of metallothionein using trace metals, amino acids and Vitamin B-6.

Pyrrole Disorder

A common feature of many behavior and emotional disorders is pyroluria, an inborn error of pyrrole chemistry which results in a dramatic deficiency of zinc, Vitamin B-6, and arachidonic acid. Common symptoms include explosive temper, emotional mood swings, poor short-term memory, and frequent infections. These patients are easily identified by their inability to tan, poor dream recall, abnormal fat distribution, and sensitivity to light and sound. The decisive laboratory test is analysis for kryptopyrroles in urine. Biomedical treatment centers on restoring the body with necessary nutrients.

Glucose Dyscontrol

Our database indicates a significant number of our patients have chronic low blood glucose levels.  This problem doesn’t appear to be the cause of behavior disorders, depression, etc., but instead is an aggravating factor which can trigger striking symptoms.  Typical symptoms include drowsiness after meals, irritability, craving for sweets, trembling, anxiety, and intermittent poor concentration and focus.  Treatment includes chromium, manganese, and other glucose-stabilizing nutrients, but the primary focus of treatment is on diet.  These patients benefit from six or more small meals daily with emphasis on complex carbohydrates and protein.  In essence, they cannot tolerate large meals or quick sugars.  Complex carbohydrates provide the necessary glucose in a slow, gradual manner and may be thought of as “time-release” sugar.

Toxic Substances

Occasionally we encounter a patient whose condition has resulted from a heavy-metal overload (lead, cadmium, mercury, etc.) or toxic levels of pesticides or other organic chemicals. Our database indicates that persons with a metallothionein disorder are especially sensitive to toxic metals, and that over-methylation is associated with severe chemical sensitivities. Effective treatment requires a three-part approach: (1) avoidance of additional exposures, (2) biochemical treatment to hasten the exit of the toxic from the body, and (3) correction of underlying chemical imbalances to minimize future vulnerability to the toxic.

Malabsorption

Although only 10% of our database case histories involve serious malabsorption, more than 90% of autistics exhibit this problem.  There are three primary classes of absorption problems: (1) stomach problems, including excessive or insufficient HCl levels, (2) incomplete digestion in the small intestine, and (3) problems at the brush-border of the intestine where most nutrients are absorbed into the portal blood stream.  The consequences can include nutrient deficiencies, irritation of the intestinal tract, candida, and mental health problems. Incomplete breakdown of protein and fats can adversely affect brain neurotransmission, and is associated with impulsivity and academic underachievement.  Treatment depends on the type of malabsorption present and may involve adjustment of stomach HCl levels, digestive enzymes which survive stomach acid, nutrients to enhance digestion, and special diets.

Essential Fatty Acids

The brain is 20% fat (by dry weight) and these fatty substances fulfill very important functions.  The myelin sheaths which surround our brain cells contain essential fatty acids which are directly involved in receptor formation and nerve transmission.  A 1998 Symposium at the National Institute of Mental Health presented strong evidence of the important roles for omega-3 oils (especially EPA and DHA) and omega-6 oils (especially AA and DGLA) in ADHD, depression, and schizophrenia. A recent Harvard study showed EPA and DHA supplements to be more effective than psychiatric medications in combating bipolar depression.  Typical American diets usually result in insufficient omega-3 and excessive omega-6, and some nutritionists routinely recommend supplements of omega-3 oils.  However, biochemical individuality also exists with oils and certain persons are innately low in omega-6 oils.  A review of symptoms and specialized plasma and red-cell-membrane lab tests can identify individual needs.